Article

Single Nuclei Transcriptome Reveals Perturbed Brain Vascular Molecules in Alzheimer’s Disease

2021-12-29

Abstract excerpt

Blood-brain barrier (BBB) dysfunction is well-known in Alzheimer’s disease (AD), but the precise molecular changes contributing to its pathophysiology are unclear. To understand the transcriptional changes in brain vascular cells, we performed single nucleus RNA sequencing (snRNAseq) of temporal cortex tissue in 24 AD and control brains resulting in 79,751 nuclei, 4,604 of which formed three distinct vascular clus...

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Literature Corpus work: d73ffbd9-f0f7-53a3-a967-5faa4c78071f
DOI: 10.1101/2021.12.28.474255

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