Article

Cerebrovascular Single-Nucleus RNA-Seq Reveals Heat Shock Activation and Vascular Remodeling in Alzheimer’s Disease and Primary Tauopathies

2026-06-28

Abstract excerpt

Cerebrovascular alterations are widely observed in both Alzheimer’s Disease (AD) and primary tauopathies. Here, we hypothesized that mechanisms of cerebrovascular alterations are shared between AD and primary tauopathies. We performed single-nucleus RNA sequencing of postmortem human inferior temporal gyrus to characterize transcriptomic changes across cerebrovascular cell types in AD and primary tauopathies (Cor...

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Literature Corpus work: 8028a45f-1313-51d9-9cf6-93cc9cfb82d8
DOI: 10.64898/2026.06.26.734052

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