Article

Inflammatory reprogramming of human brain endothelial cells compromises blood–brain barrier integrity in Alzheimer’s disease

2025-09-28

Abstract excerpt

<h4>Summary</h4> Blood-brain barrier (BBB) dysfunction is an early feature of Alzheimer’s disease (AD), yet the endothelial gene-regulatory programs involved remain incompletely understood. We integrate postmortem human single-nucleus transcriptomics with iPSC-based BBB models to define a conserved, inflammation-driven pathway that compromises barrier integrity. We identify an NF-κB-associated endothelial gene mo...

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Literature Corpus work: 1a10e6f5-92eb-5c18-be84-cc2e309f721c
DOI: 10.1101/2025.09.26.678918

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