Article

Acid sensing ion channel 1a is a key mediator of cardiac ischemia-reperfusion injury

2019-12-10

Abstract excerpt

The proton-gated acid-sensing ion channel 1a (ASIC1a) is implicated in the injury response to cerebral ischemia but little is known about its role in cardiac ischemia. We provide genetic evidence that ASIC1a is involved in myocardial ischemia-reperfusion injury (IRI) and show that pharmacological inhibition of ASIC1a yields robust cardioprotection in rodent and human models of cardiac ischemia, resulting in improv...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: de9c61a3-1c85-5209-b113-cfc0ab728242
DOI: 10.1101/869826

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Acid sensing ion channel 1a is a key mediator of cardiac ischemia-reperfusion injuryDOI 10.1101/869826Read

Therapeutic Inhibition of Acid-Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury.Semantic proximity Read

ASIC1a channel in Age-Related Diseases: Therapeutic ImplicationsSemantic proximity Read

Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death.Semantic proximity Read

Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.Semantic proximity Read

Human ASIC1a mediates stronger acid-induced responses as compared with mouse ASIC1a.Semantic proximity Read

Endogenous arginine-phenylalanine-amide-related peptides alter steady-state desensitization of ASIC1a.Semantic proximity Read

A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neuronsSemantic proximity Read

A naturally occurring mutation in ATP synthase subunit c is associated with increased damage following hypoxia/reoxygenation in STEMI patients.Semantic proximity Read

LncRNA ZFAS1 as a SERCA2a Inhibitor to Cause Intracellular Ca2+ Overload and Contractile Dysfunction in a Mouse Model of Myocardial Infarction.Semantic proximity Read

Genetic exploration of the role of acid-sensing ion channels.Semantic proximity Read

Identification of a glutamic acid repeat polymorphism of ALMS1 as a novel genetic risk marker for early-onset myocardial infarction by genome-wide linkage analysis.Semantic proximity Read

Knockdown of acid-sensing ion channel 1a (ASIC1a) suppresses disease phenotype in SCA1 mouse model.Semantic proximity Read