Article
Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death.
Neuron - 23 Nov 2005
Gao Jun, Duan Bo, Wang De-Guang, Deng Xiao-Hong, Zhang Guang-Yi, Xu Lin, Xu Tian-Le
Abstract excerpt
Acid-sensing ion channels (ASICs) composed of ASIC1a subunit exhibit a high Ca(2+) permeability and play important roles in synaptic plasticity and acid-induced cell death. Here, we show that ischemia enhances ASIC currents through the phosphorylation at Ser478 and Ser479 of ASIC1a, leading to exacerbated ischemic cell death. The phosphorylation is catalyzed by Ca(2+)/calmodulin-dependent protein kinase II...
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