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Article

Human ASIC1a mediates stronger acid-induced responses as compared with mouse ASIC1a.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2018

Xu Yuanyuan, Jiang Yu-Qing, Li Ce, He Mindi, Rusyniak W George, Annamdevula Naga, Ochoa Juan, Leavesley Silas J, Xu Jiangping, Rich Thomas C, Lin Mike T, Zha Xiang-Ming

Abstract excerpt

Acid-sensing ion channels (ASICs) are the major proton receptor in the brain and a key mediator of acidosis-induced neuronal injuries in disease. Most of published data on ASIC function came from studies performed in mice, and relatively little is known about potential differences between human and mouse ASICs (hASIC and mASIC, respectively). This information is critical for us to better interpret the functional...

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Identifiers

PMID: 29447005
DOI: 10.1096/fj.201701367R
PMCID: PMC5998965

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