Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endogenous arginine-phenylalanine-amide-related peptides alter steady-state desensitization of ASIC1a.

The Journal of biological chemistry - 25 Jan 2008

Sherwood Thomas W, Askwith Candice C

Abstract excerpt

The acid-sensing ion channels (ASICs) are proton-gated, voltage-insensitive cation channels expressed throughout the nervous system. ASIC1a plays a role in learning, pain, and fear-related behaviors. In addition, activation of ASIC1a during prolonged acidosis following cerebral ischemia induces n...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acid Sensing Ion Channels
Share to Acidosis
Share to Amides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain Ischemia

Share to Learning

Share to Neuropeptides

Source

Identifiers

PMID: 17984098
DOI: 10.1074/jbc.M705118200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17984098-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endogenous arginine-phenylalanine-amide-related peptides alter steady-state desensitization of ASIC1a.PMID 17984098Read ↗

Conformational changes in the lower palm domain of ASIC1a contribute to desensitization and RFamide modulation.Semantic proximity Read ↗

Dynamic conformational changes of acid-sensing ion channels in different desensitizing conditionsSemantic proximity Read ↗

Dynamic conformational changes of acid-sensing ion channels in different desensitizing conditions.Semantic proximity Read ↗

Protonation controls ASIC1a activity via coordinated movements in multiple domains.Semantic proximity Read ↗

Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1.Semantic proximity Read ↗

Mutation of a conserved Gln residue does not abolish desensitization of acid-sensing ion channel 1Semantic proximity Read ↗

Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.Semantic proximity Read ↗

Conformational plasticity of human acid-sensing ion channel 1aSemantic proximity Read ↗

ASIC1a channel in Age-Related Diseases: Therapeutic ImplicationsSemantic proximity Read ↗

Human ASIC1a mediates stronger acid-induced responses as compared with mouse ASIC1a.Semantic proximity Read ↗

Acid sensing ion channel 1a is a key mediator of cardiac ischemia-reperfusion injurySemantic proximity Read ↗

Extracellular chloride modulates the desensitization kinetics of acid-sensing ion channel 1a (ASIC1a).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.