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Article

LncRNA ZFAS1 as a SERCA2a Inhibitor to Cause Intracellular Ca2+ Overload and Contractile Dysfunction in a Mouse Model of Myocardial Infarction.

Circulation research - 11 May 2018

Zhang Ying, Jiao Lei, Sun Lihua, Li Yanru, Gao Yuqiu, Xu Chaoqian, Shao Yingchun, Li Mengmeng, Li Chunyan, Lu Yanjie, Pan Zhenwei, Xuan Lina, Zhang Yiyuan, Li Qingqi, Yang Rui, Zhuang Yuting, Zhang Yong, Yang Baofeng

Abstract excerpt

RATIONALE: Ca2+ homeostasis-a critical determinant of cardiac contractile function-is critically regulated by SERCA2a (sarcoplasmic reticulum Ca2+-ATPase 2a). Our previous study has identified ZFAS1 as a new lncRNA biomarker of acute myocardial infarction (MI). OBJECTIVE: To evaluate the effects of ZFAS1 on SERCA2a and the associated Ca2+ homeostasis and cardiac contractile function in the setting of MI. METHODS...

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PMID: 29475982
DOI: 10.1161/CIRCRESAHA.117.312117
PMCID: PMC5959220

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