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Article

A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons

11 Mar 2008

Abstract excerpt

Neurodegenerative diseases and noxious stimuli to the brain enhance transcription of serum- and glucocorticoid-induced kinase-1 (SGK1). Here, we report that the SGK1 gene encodes a brain-specific additional isoform, SGK1.1, which exhibits distinct regulation, properties, and functional effects. SGK1.1 decreases expression of the acid-sensing ion channel-1 (ASIC1); thereby, SGK1.1 may limit neuronal injury...

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PMID: 18334630
DOI: 10.1073/pnas.0800958105

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