Article

ASIC1a channel in Age-Related Diseases: Therapeutic Implications

2022-04-28

Abstract excerpt

Age-related diseases have become more common with the advancing age of the worldwide population. Such diseases involve multiple organs, with tissue degeneration and cellular apoptosis. To date, there is a general lack of effective drugs for treatment of most age-related diseases and there is therefore an urgent need to identify novel drug targets for improved treatment. Acid-sensing ion channel 1a (ASIC1a) is a de...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1f04cd70-44da-52d1-8364-54f0290211bf
DOI: 10.22541/au.165115867.78502146/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ASIC1a channel in Age-Related Diseases: Therapeutic ImplicationsDOI 10.22541/au.165115867.78502146/v1Read

Human ASIC1a mediates stronger acid-induced responses as compared with mouse ASIC1a.Semantic proximity Read

Acid sensing ion channel 1a is a key mediator of cardiac ischemia-reperfusion injurySemantic proximity Read

Conformational plasticity of human acid-sensing ion channel 1aSemantic proximity Read

Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism.Semantic proximity Read

Computational elucidation, mutational and hot spot-based designing of potential inhibitors against human acid-sensing ion channels (hASIC-1a) to treat various physiological conditions.Semantic proximity Read

Acidotoxicity and acid-sensing ion channels contribute to motoneuron degeneration.Semantic proximity Read

Ion Channels in Neurological Disorders.Semantic proximity Read

Involvement of Acid-Sensing Ion Channel 1a Contribute to The Effect of Extracellular Acidosis on Vascular Endothelialcell Damage of Henoch-Schönlein Purpura PatientsSemantic proximity Read

The contact region between three domains of the extracellular loop of ASIC1a is critical for channel function.Semantic proximity Read

Endogenous arginine-phenylalanine-amide-related peptides alter steady-state desensitization of ASIC1a.Semantic proximity Read

Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1.Semantic proximity Read

Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.Semantic proximity Read