Article
Knockdown of acid-sensing ion channel 1a (ASIC1a) suppresses disease phenotype in SCA1 mouse model.
Cerebellum (London, England) - 1 Aug 2014
Vig Parminder J S, Hearst Scoty M, Shao Qingmei, Lopez Maripar E
Abstract excerpt
The mutated ataxin-1 protein in spinocerebellar ataxia 1 (SCA1) targets Purkinje cells (PCs) of the cerebellum and causes progressive ataxia due to loss of PCs and neurons of the brainstem. The exact mechanism of this cellular loss is still not clear. Currently, there are no treatments for SCA1; however, understanding of the mechanisms that regulate SCA1 pathology is essential for devising new therapies for SCA1...
Topics
- Acid Sensing Ion Channels
- Animals
- Calbindin 1
- Cerebellum
- Disease Models, Animal
- Gene Expression Regulation
- Mice
- Mice, Transgenic
- Motor Activity
- Movement Disorders
- Parvalbumins