Therapeutic Inhibition of Acid-Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury.

doi:10.1161/CIRCULATIONAHA.121.054360

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Article

Therapeutic Inhibition of Acid-Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury.

Circulation - 21 Sept 2021

Redd Meredith A, Scheuer Sarah E, Saez Natalie J, Yoshikawa Yusuke, Chiu Han Sheng, Gao Ling, Hicks Mark, Villanueva Jeanette E, Joshi Yashutosh, Chow Chun Yuen, Cuellar-Partida Gabriel, Peart Jason N, See Hoe Louise E, Chen Xiaoli, Sun Yuliangzi, Suen Jacky Y, Hatch Robert J, Rollo Ben, Xia Di, Alzubaidi Mubarak A H, Maljevic Snezana, Quaife-Ryan Gregory A, Hudson James E, Porrello Enzo R, White Melanie Y, Cordwell Stuart J, Fraser John F, Petrou Steven, Reichelt Melissa E, Thomas Walter G, King Glenn F, Macdonald Peter S, Palpant Nathan J

Abstract excerpt

BACKGROUND: Ischemia-reperfusion injury (IRI) is one of the major risk factors implicated in morbidity and mortality associated with cardiovascular disease. During cardiac ischemia, the buildup of acidic metabolites results in decreased intracellular and extracellular pH, which can reach as low as 6.0 to 6.5. The resulting tissue acidosis exacerbates ischemic injury and significantly affects cardiac function....

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PMID: 34264749
DOI: 10.1161/CIRCULATIONAHA.121.054360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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