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Article

Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Feb 2011

Duan Bo, Wang Yi-Zhi, Yang Tao, Chu Xiang-Ping, Yu Ye, Huang Yu, Cao Hui, Hansen Jillian, Simon Roger P, Zhu Michael X, Xiong Zhi-Gang, Xu Tian-Le

Abstract excerpt

Ischemic brain injury is a major problem associated with stroke. It has been increasingly recognized that acid-sensing ion channels (ASICs) contribute significantly to ischemic neuronal damage, but the underlying mechanism has remained elusive. Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular...

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Identifiers

PMID: 21307247
DOI: 10.1523/JNEUROSCI.4351-10.2011
PMCID: PMC3101878

Genes

ASIC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.PMID 21307247Read ↗

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