A naturally occurring mutation in ATP synthase subunit c is associated with increased damage following hypoxia/reoxygenation in STEMI patients.

doi:10.1016/j.celrep.2021.108983

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Article

A naturally occurring mutation in ATP synthase subunit c is associated with increased damage following hypoxia/reoxygenation in STEMI patients.

Cell reports - 13 Apr 2021

Morciano Giampaolo, Pedriali Gaia, Bonora Massimo, Pavasini Rita, Mikus Elisa, Calvi Simone, Bovolenta Matteo, Lebiedzinska-Arciszewska Magdalena, Pinotti Mirko, Albertini Alberto, Wieckowski Mariusz R, Giorgi Carlotta, Ferrari Roberto, Galluzzi Lorenzo, Campo Gianluca, Pinton Paolo

Abstract excerpt

Preclinical models of ischemia/reperfusion injury (RI) demonstrate the deleterious effects of permeability transition pore complex (PTPC) opening in the first minutes upon revascularization of the occluded vessel. The ATP synthase c subunit (Csub) influences PTPC activity in cells, thus impacting tissue injury. A conserved glycine-rich domain in Csub is classified as critical because, when mutated, it modifies...

Topics

Aged
Animals
Base Sequence
Calcium Channels
Exons
Female
Gene Expression
Humans
Hypoxia
Introns

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Mitochondria

Mitochondrial Permeability Transition Pore

Mitochondrial Proton-Translocating ATPases

Mutation

Myocytes, Cardiac

Oxygen

Source

Open in PubMed

Identifiers

PMID: 33852870
DOI: 10.1016/j.celrep.2021.108983

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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