Article

A primed immune transcriptional program is activated in oligodendroglia in multiple sclerosis

2020-07-22

Abstract excerpt

Multiple sclerosis (MS) is a disease characterized by a targeted immune attack on myelin in the central nervous system (CNS). We have previously shown that oligodendrocytes (OLs), myelin producing cells in the CNS, and their precursors (OPCs), ac-quire disease-specific transcriptional states in MS 1,2 . To under-stand how these alternative transcriptional programs are acti-vated in disease, we performed single-ce...

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Literature Corpus work: de94a95d-a763-5a1c-b462-88437ff2aec9
DOI: 10.1101/2020.07.21.213876

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