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DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation

5 Sept 2021

Abstract excerpt

The differentiation of oligodendrocyte precursor cells (OPCs) into myelinating oligodendrocytes is the prerequisite for remyelination in demyelinated disorders such as multiple sclerosis (MS). Epigenetic mechanisms, such as DNA methylation, have been suggested to control the intricate network of transcription factors involved in OPC differentiation. Yet, the exact mechanism remains undisclosed. Here, we are the...

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PMID: 34482420
DOI: 10.1007/s00018-021-03927-2

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