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Dissection of multiple sclerosis genetics identifies B and CD4+ T cells as driver cell subsets

7 Jun 2022

Abstract excerpt

Abstract Background Multiple sclerosis (MS) is an autoimmune condition of the central nervous system with a well-characterized genetic background. Prior analyses of MS genetics have identified broad enrichments across peripheral immune cells, yet the driver immune subsets are unclear. Results We utilize chromatin accessibility data across hematopoietic cells to identify cell type-specific enrichments of MS...

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PMID: 35672799
DOI: 10.1186/s13059-022-02694-y

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