Article

Distinct transcriptomic and epigenomic responses of mature oligodendrocytes during disease progression in a mouse model of multiple sclerosis

2023-12-18

Abstract excerpt

Multiple sclerosis ( MS ) is a chronic demyelinating autoimmune disease that targets mature oligodendrocytes (MOLs ) and their myelin. MOLs are transcriptionally heterogeneous and can transition to immune-like states in the context of MS. However, the intricacies of their dynamics throughout disease progression remain poorly understood. Here, we employed simultaneous single-cell multiome ATAC and RNA sequencing...

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Literature Corpus work: 93809f3c-4dd8-57f5-b8b4-ed45b49b3ac9
DOI: 10.1101/2023.12.18.572120

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