Article

Dissection of multiple sclerosis genetics identifies B and CD4+ T cells as driver cell subsets

2021-05-25

Abstract excerpt

Multiple sclerosis (MS) is an autoimmune condition of the central nervous system with a well-characterized genetic background. Prior analyses of MS genetics have identified broad enrichments across peripheral immune cells, yet the driver immune subsets are unclear. We utilized chromatin accessibility data across hematopoietic cells to identify cell type-specific enrichments of MS genetic signals. We found that CD4...

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Literature Corpus work: 571ab6fd-fefa-5539-b75f-914edecd9a7a
DOI: 10.1101/2021.05.24.445445

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