Article
Integration of epigenetic and genetic profiles identifies multiple sclerosis disease-critical cell types and genes.
Communications biology - 30 Mar 2023
Ma Qin, Shams Hengameh, Didonna Alessandro, Baranzini Sergio E, Cree Bruce A C, Hauser Stephen L, Henry Roland G, Oksenberg Jorge R
Abstract excerpt
Genome-wide association studies (GWAS) successfully identified multiple sclerosis (MS) susceptibility variants. Despite this notable progress, understanding the biological context of these associations remains challenging, due in part to the complexity of linking GWAS results to causative genes and cell types. Here, we aimed to address this gap by integrating GWAS data with single-cell and bulk chromatin...
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