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Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility

31 Jan 2022

Abstract excerpt

Multiple sclerosis (MS) is characterized by a targeted attack on oligodendroglia (OLG) and myelin by immune cells, which are thought to be the main drivers of MS susceptibility. We found that immune genes exhibit a primed chromatin state in single mouse and human OLG in a non-disease context, compatible with transitions to immune-competent states in MS. We identified BACH1 and STAT1 as transcription factors...

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PMID: 35093191
DOI: 10.1016/j.neuron.2021.12.034

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