Article

Dysregulation of transcription networks regulating oligodendrogenesis in age-related decline in CNS remyelination

2025-11-14

Abstract excerpt

In demyelinating diseases like multiple sclerosis (MS), efficient remyelination is critical for functional recovery. Remyelination efficiency declines with age, and is linked to progressive disability. The gene regulatory network underlying remyelination, and how it is altered with aging, remains unclear. Here we present a comparative single-nucleus RNA and ATAC sequencing analysis of remyelination in young and ag...

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Literature Corpus work: 355fd873-6bf9-5c5b-85da-3dfeadc00374
DOI: 10.1101/2025.11.14.688494

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