Article

From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions

2023-01-13

Abstract excerpt

<h4>Introduction</h4> In the progressive phase of multiple sclerosis (MS), the hampered differentiation capacity of oligodendrocyte precursor cells (OPCs) eventually results in remyelination failure. We have previously shown that DNA methylation of Id2/Id4 is highly involved in OPC differentiation and remyelination. In this study, we took an unbiased approach by determining genome-wide DNA methylation patterns w...

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Literature Corpus work: 88cc274a-0122-53ca-83ba-c885f188807b
DOI: 10.1101/2023.01.12.523740

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