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Deep characterization of paired chromatin and transcriptomes in four immune cell types from multiple sclerosis patients.

Epigenomics - 1 Oct 2021

Fernandes Sunjay Jude, Ericsson Matilda, Khademi Mohsen, Jagodic Maja, Olsson Tomas, Gomez-Cabrero David, Kockum Ingrid, Tegnér Jesper

Abstract excerpt

Background: The putative involvement of chromatin states in multiple sclerosis (MS) is thus far unclear. Here we determined the association of chromatin-accessibility with concurrent genetic, epigenetic and transcriptional events. Material & methods: We generated paired assay for transposase-accessible chromatin sequencing and RNA-sequencing profiles from sorted blood immune CD4+ and CD8+ T cells, CD14+...

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Identifiers

PMID: 34676774
DOI: 10.2217/epi-2021-0205

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