Article
Exploring the role of the epigenome in multiple sclerosis: a window onto cell-specific transcriptional potential.
Journal of neuroimmunology - 15 Jul 2012
Kaliszewska Anna, De Jager Philip L
Abstract excerpt
The field of epigenomics involves the study of chromatin, the three dimensional complex of DNA, protein and non-coding RNAs that determines the accessibility of DNA by the transcriptional machinery. The epigenome varies from cell to cell and reflects the effect of external stimuli on cell fate and cell state. Thanks to emerging platforms and analysis methods, the systematic characterization of chromatin...
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