Article

Epigenomic regulation of human oligodendrocyte myelination properties – relation to age and lineage

2025-09-04

Abstract excerpt

Multiple sclerosis (MS) is characterized by immune-mediated injury to myelin and oligodendrocytes (OLs). Repair depends on the ability of OL lineage cells to form new myelin and ensheathe axons. We previously showed that late progenitors (O4+A2B5+ cells) and mature human OLs exhibit age-related differences in ensheathment capacity and vulnerability to injury. Here, we test the hypothesis that differences in chroma...

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Literature Corpus work: bd0685ce-2da2-5fa5-b1e6-43aec99843e6
DOI: 10.1101/2025.09.04.674347

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