Article

An isogenic collection of pluripotent stem cell lines with elevated α-synuclein expression

2022-02-10

Abstract excerpt

α-Synuclein (αSyn) is a small, disordered protein that becomes aggregated in Lewy body diseases, such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Human induced pluripotent stem cells (hiPSCs) potentially provide a tractable disease model to monitor early molecular changes associated with PD/DLB. We and others have previously derived hiPSC lines from patients with duplication and triplication o...

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Literature Corpus work: de586a66-e9f4-5945-9a2d-c27db74be760
DOI: 10.1101/2022.02.10.479903

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