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Article

Midbrain organoids with an SNCA gene triplication model key features of synucleinopathy

23 Sept 2021

Abstract excerpt

Abstract SNCA, the first gene associated with Parkinson’s disease, encodes the α-synuclein protein, the predominant component within pathological inclusions termed Lewy bodies. The presence of Lewy bodies is one of the classical hallmarks found in the brain of patients with Parkinson’s disease, and Lewy bodies have also been observed in patients with other synucleinopathies. However, the study of α-synuclein...

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PMID: 34632384
DOI: 10.1093/braincomms/fcab223

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