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Article

Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation.

Human molecular genetics - 15 Mar 2007

Schneider Bernard L, Seehus Corey R, Capowski Elizabeth E, Aebischer Patrick, Zhang Su-Chun, Svendsen Clive N

Abstract excerpt

Missense mutations and extra copies of the alpha-Synuclein gene result in Parkinson disease (PD). Human stem and progenitor cells can be expanded from embryonic tissues and provide a source of non-transformed neural cells to explore the effects of these pathogenic mutations specifically in human nervous tissue. We over-expressed the wild type, A53T and A30P forms of alpha-synuclein in expanded populations of...

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Identifiers

PMID: 17309880
DOI: 10.1093/hmg/ddm008

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FGF8
SHH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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