Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells

26 Nov 2015

Abstract excerpt

We have assessed the impact of α-synuclein overexpression on the differentiation potential and phenotypic signatures of two neural-committed induced pluripotent stem cell lines derived from a Parkinson's disease patient with a triplication of the human SNCA genomic locus. In parallel, comparative studies were performed on two control lines derived from healthy individuals and lines generated from the patient...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nerve injury and regeneration
Share to Nuclear Receptors and Signaling
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26610207
DOI: 10.1038/cddis.2015.318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cellsPMID 26610207Read ↗

Higher Vulnerability and Stress Sensitivity of Neuronal Precursor Cells Carrying an Alpha-Synuclein Gene TriplicationSemantic proximity Read ↗

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locusSemantic proximity Read ↗

Synaptic decline precedes dopaminergic neuronal loss in human midbrain organoids harboring a triplication of the <i>SNCA</i> geneSemantic proximity Read ↗

SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate α-synuclein and are susceptible to oxidative stress.Semantic proximity Read ↗

Midbrain organoids with an SNCA gene triplication model key features of synucleinopathySemantic proximity Read ↗

Midbrain organoids with an <i>SNCA</i> gene triplication model key features of synucleinopathySemantic proximity Read ↗

Autophagy Dysfunction in iPSCs-Derived Neurons and Midbrain Organoids Carrying a <i>SNCA</i> TriplicationSemantic proximity Read ↗

Modeling Parkinson's disease using induced pluripotent stem cells.Semantic proximity Read ↗

Derivation, Characterization, and Neural Differentiation of Integration-Free Induced Pluripotent Stem Cell Lines from Parkinson's Disease Patients Carrying SNCA, LRRK2, PARK2, and GBA Mutations.Semantic proximity Read ↗

Alpha-synuclein induces the unfolded protein response in Parkinson’s disease SNCA triplication iPSC-derived neuronsSemantic proximity Read ↗

Protein aggregation and calcium dysregulation are the earliest hallmarks of synucleinopathy in human midbrain dopaminergic neuronsSemantic proximity Read ↗

An isogenic collection of pluripotent stem cell lines with elevated α-synuclein expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.