Article

Midbrain organoids with an <i>SNCA</i> gene triplication model key features of synucleinopathy

2021-04-12

Abstract excerpt

SNCA, the first gene associated with Parkinson’s disease, encodes the α-synuclein (α-syn) protein, the predominant component within pathological inclusions termed Lewy bodies (LBs). The presence of LBs is one of the classical hallmarks found in the brain of patients with Parkinson’s disease, and LBs have also been observed in patients with other synucleinopathies. However, the study of α-syn pathology in cells has...

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Literature Corpus work: ee927c15-0aec-5b3c-8221-80e4e5dcc68a
DOI: 10.1101/2021.04.12.439480

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