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Article

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

23 Aug 2011

Abstract excerpt

A major barrier to research on Parkinson's disease is inaccessibility of diseased tissue for study. One solution is to derive induced pluripotent stem cells from patients and differentiate them into neurons affected by disease. Triplication of SNCA, encoding α-synuclein, causes a fully penetrant, aggressive form of Parkinson's disease with dementia. α-Synuclein dysfunction is the critical pathogenic event in...

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PMID: 21863007
DOI: 10.1038/ncomms1453

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