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Article

Cellular models of alpha‐synuclein toxicity and aggregation

2 Jul 2019

Abstract excerpt

Misfolding and aggregation of alpha-synuclein (α-synuclein) with concomitant cytotoxicity is a hallmark of Lewy body related disorders such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Although it plays a pivotal role in pathogenesis and disease progression, the function of α-synuclein and the molecular mechanisms underlying α-synuclein-induced neurotoxicity in these diseases...

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PMID: 31265132
DOI: 10.1111/jnc.14806

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