Article

Modeling interregional propagation of α-synuclein in human striatal–midbrain assembloids

2026-05-11

Abstract excerpt

Parkinson’s disease is characterized by the progressive degeneration of dopaminergic (DA) neurons in the substantia nigra that project to the striatum. Postmortem studies have found that α-synuclein pathology spreads across brain regions in a prion-like manner. Human three-dimensional neural tissues provide experimentally tractable platforms for clarifying the molecular pathology of synucleinopathy that overcome t...

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Literature Corpus work: 088896b1-a59f-51a6-92cf-266d2ed11db8
DOI: 10.64898/2026.05.11.723670

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