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Synaptic decline precedes dopaminergic neuronal loss in human midbrain organoids harboring a triplication of the <i>SNCA</i> gene

2021-07-15

Abstract excerpt

1. Increased levels of the protein alpha-synuclein (α-syn) are associated with the development of neurodegenerative diseases like Parkinson’s disease (PD). In physiological conditions, α-syn modulates synaptic plasticity, neurogenesis and neuronal survival. However, its pathogenic accumulation and aggregation results in toxicity and neurodegeneration. Here, we used a PD patient specific midbrain organoid model der...

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Literature Corpus work
23e1028b-35b7-55b0-8c26-d64bf6523f40
DOI
10.1101/2021.07.15.452499
Open publication

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Synaptic decline precedes dopaminergic neuronal loss in human midbrain organoids harboring a triplication of the <i>SNCA</i> geneDOI 10.1101/2021.07.15.452499
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