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Article

Protocol for generation of PD modeling induced neurons and detection of α-synuclein forms.

STAR protocols - 20 Dec 2024

Nardi Francesco V, Maisumu Gulimiheranmu, Zhou You, Liang Bo, Yakoub Abraam M

Abstract excerpt

Alpha-synuclein (α-Syn) is an important molecule in the pathogenesis of Parkinson's disease and Alzheimer's disease-related dementias such as Lewy body dementia, forming multiple pathological species. In vitro disease models, including human neurons and α-Syn-transfected cells, are instrumental to understand synucleinopathies or test new therapies. Here, we provide a detailed protocol to generate human neurons...

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Identifiers

PMID: 39549235
DOI: 10.1016/j.xpro.2024.103447
PMCID: PMC11609654

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