Article
Tethered-hopping model for protein-DNA binding and unbinding based on Sox2-Oct1-Hoxb1 ternary complex simulations.
Biophysical journal - 7 Apr 2010
Lian Peng, Liu Limin Angela, Shi Yongxiang, Bu Yuxiang, Wei Dongqing
Abstract excerpt
The sliding and hopping models encapsulate the essential protein-DNA binding process for binary complex formation and dissociation. However, the effects of a cofactor protein on the protein-DNA binding process that leads to the formation of a ternary complex remain largely unknown. Here we investigate the effect of the cofactor Sox2 on the binding and unbinding of Oct1 with the Hoxb1 control element. We simulate...
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