Article

PolyA/polyQ-mediated conformational rewiring regulates DNA engagement and drives aggregation in the neuronal transcription factor Ascl1

2026-05-14

Abstract excerpt

<h4>ABSTRACT</h4> Ascl1 is a pioneer transcription factor that drives neuronal fate decisions, yet the structural basis of its activity remains elusive. Besides the basic helix–loop–helix (bHLH) domain which dimerizes with other transcription factors and binds DNA, Ascl1 contains long low-complexity intrinsically disordered regions (IDRs), including a polyA/polyQ tract of unknown function. Here we apply single-mo...

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Literature Corpus work: 4c778075-b6d8-5ec2-a527-025251de00da
DOI: 10.64898/2026.05.11.724289

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