Article

A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity

2020-11-12

Abstract excerpt

Few genetically dominant mutations involved in human disease have been fully explained at the molecular level. In cases where the mutant gene encodes a transcription factor, the dominant-negative mode of action of the mutant protein is particularly poorly understood. Here, we studied the genome-wide mechanism underlying a dominant-negative form of the SOX18 transcription factor (SOX18 RaOp ) responsible for both...

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Literature Corpus work: 9595a1ab-a06c-557d-b9ca-5c10763e0be7
DOI: 10.1101/2020.11.11.378968

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