Article

Cep192 insufficiency underlies haploid instability in human cells

2026-04-28

Abstract excerpt

<title>Abstract</title> <p>Mammalian somatic haploid cells offer advantages for genome engineering, yet rapid diploidization limits their utility. Here, we reveal that a haploidy-specific attenuation of mitotic spindle bipolarization, independent of previously characterized centrosome loss, underlies haploid instability in human cells. Comparative imaging and structure-function analyses demonstrate that the halve...

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Literature Corpus work: dda19ea1-29a2-56e2-b016-b1a7ab00d528
DOI: 10.21203/rs.3.rs-9217489/v1

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