Article

A pivotal contribution of proteostasis failure and mitochondrial dysfunction to chromosomal instability-induced microcephaly

2025-03-18

Abstract excerpt

<h4>Summary</h4> Mosaic variegated aneuploidy (MVA), a rare human congenital disorder that causes microcephaly, is characterized by extensive abnormalities in chromosome number and results from mutations in genes involved in accurate mitotic chromosome segregation. To characterize the cellular mechanisms underlying this disease, here we generated a Drosophila model of microcephaly caused by the depletion of a si...

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Literature Corpus work: 749e77c8-90c1-5694-a04d-ff7e1f5f27ea
DOI: 10.1101/2025.03.18.643858

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