Article

TPX2 Amplification-Driven Aberrant Mitosis in Culture Adapted Human Embryonic Stem Cells With Gain of 20q11.21

2021-11-08

Abstract excerpt

<title>Abstract</title> <p>Despite highly effective machinery for the maintenance of genome integrity in human embryonic stem cells (hESCs), the frequency of genetic aberrations during <italic>in-vitro</italic> culture has been a serious issue for future clinical applications. By passaging hESCs over a broad range of timepoints, we found that mitotic aberrations, such as the delay of mitosis, multipolar centrosom...

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Literature Corpus work: a5abcaca-c652-580d-a27e-15ac0abd4750
DOI: 10.21203/rs.3.rs-982680/v1

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