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Centrosome depletion rewires mitosis to impose dependence on the AURKA–TPX2 axis

2026-05-06

Abstract excerpt

Centrosomes are key microtubule-organizing centers required for accurate spindle assembly and chromosome segregation, and their dysfunction in cancer creates therapeutic vulnerabilities. Prior work identified a synthetic lethal interaction between TRIM37 overexpression and Polo-like kinase 4 inhibition (PLK4i) in 17q23-amplified tumors, motivating the clinical development of centrosome-depleting PLK4 inhibitors. H...

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Literature Corpus work
a0998a19-ac1c-5596-af9b-e30afa2f0222
DOI
10.64898/2026.05.02.722379
Open publication

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Centrosome depletion rewires mitosis to impose dependence on the AURKA–TPX2 axisDOI 10.64898/2026.05.02.722379
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