Article

Less is More: Nek2A Unclusters Extra Centrosomes and Induces Cell Death in Cancer Cells via KIF2C Interaction

2023-11-21

Abstract excerpt

<h4>ABSTRACT</h4> Unlike normal cells, cancer cells frequently exhibit extra centrosomes, leading to formation of multipolar spindles that can trigger cell death. Nevertheless, they manage to divide successfully and escape the deadly consequences of unequal segregation of genomic material by coalescing their extra centrosomes into two poles. This unique trait of cancer cells presents a promising target for cancer...

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Literature Corpus work: cafd1230-fbb5-519b-bbd5-de8fe0d137d4
DOI: 10.1101/2023.11.21.567992

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