Article
TPX2 Amplification-Driven Aberrant Mitosis in Long-Term Cultured Human Embryonic Stem Cells
2021-02-23
Abstract excerpt
Although human embryonic stem cells (hESCs) are equipped with highly effective machinery for the maintenance of genome integrity, the frequency of genetic aberrations during long-term in vitro hESC culture has been a serious issue that raises concerns over their safety in future clinical applications. By passaging hESCs over a broad range of timepoints, we found that mitotic aberrations, such as the delay of mito...
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Identifiers and source
- Literature Corpus work
- 33a4e870-fa2e-5f51-a8e5-39efac12d45c
- DOI
- 10.1101/2021.02.22.432205