Article

Cep192 insufficiency underlies haploid instability in human cells

2026-03-20

Abstract excerpt

Mammalian somatic haploid cells offer advantages for genome engineering, yet rapid diploidization limits their utility. Here, we reveal that a haploidy-specific attenuation of mitotic spindle bipolarization, independent of previously characterized centrosome loss, underlies haploid instability in human cells. Comparative imaging and structure-function analyses demonstrate that the halved absolute dosage of the per...

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Literature Corpus work: 649be3c8-0552-5e84-92f6-1dd192bcdb57
DOI: 10.64898/2026.03.18.712690

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