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The G protein biased serotonin 5-HT 2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice

2023-06-05

Abstract excerpt

<h4>ABSTRACT</h4> There is now evidence from multiple Phase II clinical trials that psychedelic drugs can exert long-lasting anxiolytic, anti-depressant, and anti-drug abuse (nicotine and ethanol) effects in patients. Despite these benefits, the hallucinogenic actions of these drugs at the serotonin 2A receptor (5-HT2AR) limit their clinical use in diverse settings. Activation of the 5-HT2AR can stimulate both G...

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Literature Corpus work: dd5d0487-a9c3-5d38-a9bd-7aa615e4b1a2
DOI: 10.1101/2023.06.01.543310

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