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Increased 5-HT <sub>2A</sub> receptor signalling efficacy differentiates serotonergic psychedelics from non-psychedelics

2024-06-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and Purpose</h4> Serotonergic psychedelic drugs are under renewed investigation for the potential treatment of several psychiatric disorders. While all serotonergic psychedelics have 5-HT 2A receptor activity, the explanation for why some 5-HT 2A receptor agonists are not psychedelic is unknown. To address this question, we investigated the 5-HT 2A receptor signalling bias and...

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Literature Corpus work
7f1c679a-fdcb-502e-927f-c466c63270b1
DOI
10.1101/2024.06.13.594677
Open publication

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Increased 5-HT <sub>2A</sub> receptor signalling efficacy differentiates serotonergic psychedelics from non-psychedelicsDOI 10.1101/2024.06.13.594677
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