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Desloratadine Rescues Schizophrenia-like Phenotypes by Inhibiting the Pathogenic 5-HT2AR-PI3K/AKT/mTOR Signaling Axis.

Molecular neurobiology - 24 Jun 2026

Yao Yuhan, Zhao Weiliang, Chen Junyang, Wang Shentong, Song Zhiyao, Sun Lin, Hu Yubo, Li Longyun

Abstract excerpt

The 5-HT2A receptor (5-HT2AR) is a validated target in schizophrenia (SCZ); however, the therapeutic potential of repurposed drugs targeting this pathway remains underexplored. Here, we show that the antihistamine desloratadine (DLT) robustly ameliorates a full spectrum of SCZ-like behavioral deficits in an MK-801-induced male mouse model. Single-nucleus RNA sequencing (snRNA-seq) analysis revealed 5-HT2AR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42340538
DOI: 10.1007/s12035-026-06027-z
PMCID: PMC13294246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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