Article

G Protein-Coupled Receptors in Addiction Neurobiology: Mechanisms, Therapeutic Targets, and Advances in Pharmacotherapy

2025-04-07

Abstract excerpt

G protein-coupled receptors (GPCRs) are central regulators of neurotransmission and neuroplasticity, influencing the pharmacodynamics of psychoactive substances. As key nodes in signal transduction, they modulate second messenger systems, ion channel activity, and synaptic communication. Despite extensive research on GPCRs as therapeutic targets, their specific role in addiction-related neuroadaptations remains in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f7dadce3-5ac1-527c-819b-85f65360302c
DOI: 10.22541/au.174402936.68512104/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

G Protein-Coupled Receptors in Addiction Neurobiology: Mechanisms, Therapeutic Targets, and Advances in PharmacotherapyDOI 10.22541/au.174402936.68512104/v1Read

Opioid receptors.Semantic proximity Read

[Neurobiology and genetics of addiction].Semantic proximity Read

An emerging multi-omic understanding of the genetics of opioid addictionSemantic proximity Read

GPCRs: The most promiscuous druggable receptor of the mankindSemantic proximity Read

G‐protein‐coupled receptors: past, present and futureSemantic proximity Read

Genetics of dopamine receptors and drug addiction: a comprehensive review.Semantic proximity Read

Current Understanding of the Neurobiology of Opioid Use Disorder: an OverviewSemantic proximity Read

Key aspects of modern GPCR drug discoverySemantic proximity Read

Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics.Semantic proximity Read

Genetics of dopamine receptors and drug addiction.Semantic proximity Read

The current state of GPCR ‐based drug discovery to treat metabolic diseaseSemantic proximity Read

The Habenular Receptor GPR151 Regulates Addiction Vulnerability Across Drug ClassesSemantic proximity Read